1. Leprosy Post-Exposure Prophylaxis (LPEP), Dadra & Nagar Haveli
LPEP was implemented in Union Territory (UT) of Dadra and Nagar Haveli (DNH) with the objective to assess the operational feasibility of the administration of a Single Dose Rifampicin (SDR) as post-exposure prophylaxis (PEP) to the contacts of leprosy cases. This study was implemented in close coordination with Govt of DNH, Central Leprosy Division with support from German Leprosy and TB Relief Association (GLRA), Netherlands Leprosy Relief Foundation (NLR), and Erasmus with the financial support from Novartis Foundation.Overall, the contact examination and SDR administration to eligible contacts was carefully carried out. A total of 1530 leprosy cases (index cases) registered in NLEP DNH were enrolled in the study until December 2017 & a total of 37,163 contacts were examined out of which 27231 eligible contacts were administered SDR No. adverse effects were reported by any contact given SDR. Seeing the feasibility of LPEP, Central Leprosy Division issued the guidelines in 2017 to roll LPEP in 163 districts across India where Leprosy Case Detection Campaign (LCDC) was being carried out.
2. Molecular Epidemiological Study in Purulia, West Bengal (PuMEL Project)
This study is to evaluate the role of host factors as potential markers of susceptibility of leprosy. The objectives of the study are to assess TLR1, TLR2, TLR4, NRAMP1 and TAP1, TAP2 polymorphisms in patients presenting with leprosy and compare the polymorphisms between patients and normal individuals (genetically related and non-genetically linked) from the same community in the study area.
3. Strategies for Early Detection of Leprosy – LRI Supported study
A comparison of three types of targeted, community based health education interventions aimed at promoting early detection, supported by Leprosy Research Initiative is a collaborative project between The Leprosy Mission Trust India, Netherland Leprosy Relief and GLRA India. It is a multi-centric study and GLRA is undertaking the research in Uttar and Dakshin Dinajpur districts of West Bengal. The three interventions include Training Local practitioners (non allopathic healers); Health education to newly diagnosed leprosy patients; and Increasing awareness in the community regarding early signs of leprosy.